Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/7/21 2:30 PM | 11/7/21 2:30 PM | Toronto FC | D.C. United | 1-3 | 3 - 5 - 5 |
| 11/7/21 2:30 PM | 11/7/21 2:30 PM | CF Montreal | Orlando City | 0-2 | 3 - 5 - 5 |
| 11/7/21 2:30 PM | 11/7/21 2:30 PM | Cincinnati FC | Atlanta United FC | 1-2 | 5 - 5 - 3 |
| 11/7/21 2:30 PM | 11/7/21 2:30 PM | Nashville SC | New York Red Bulls | 1-1 | 3 - 5 - 5 |
| 11/7/21 2:30 PM | 11/7/21 2:30 PM | Columbus Crew | Chicago Fire | 2-0 | 3 - 5 - 5 |
| 11/7/21 2:30 PM | 11/7/21 2:30 PM | New York City FC | Philadelphia Union | 1-1 | 3 - 5 - 5 |
| 11/7/21 2:30 PM | 11/7/21 2:30 PM | New England Revolution | Inter Miami CF | 0-1 | 3 - 5 - 5 |
| 11/7/21 5:00 PM | 11/7/21 5:00 PM | Vancouver Whitecaps | Seattle Sounders | 1-1 | 4 - 5 - 4 |
| 11/7/21 5:00 PM | 11/7/21 5:00 PM | Los Angeles Galaxy | Minnesota United FC | 3-3 | 3 - 5 - 5 |
| 11/7/21 5:00 PM | 11/7/21 5:00 PM | Colorado Rapids | Los Angeles FC | 5-2 | 3 - 5 - 5 |
| 11/7/21 5:00 PM | 11/7/21 5:00 PM | San Jose Earthquakes | FC Dallas | 1-1 | 3 - 5 - 5 |
| 11/7/21 5:00 PM | 11/7/21 5:00 PM | Portland Timbers | Austin FC | 3-0 | 3 - 5 - 5 |
| 11/7/21 5:00 PM | 11/7/21 5:00 PM | Sporting Kansas City | Real Salt Lake | 0-1 | 3 - 5 - 5 |