Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 5/1/21 12:00 PM | 5/1/21 12:00 PM | New York Red Bulls | Chicago Fire | 2-0 | 3 - 5 - 5 |
| 5/1/21 1:00 PM | 5/1/21 1:00 PM | Real Salt Lake | Sporting Kansas City | 3-1 | 4 - 5 - 3 |
| 5/1/21 2:00 PM | 5/1/21 2:00 PM | CF Montreal | Columbus Crew | 0-0 | 3 - 5 - 4 |
| 5/1/21 2:30 PM | 5/1/21 2:30 PM | Houston Dynamo | Los Angeles FC | 1-1 | 5 - 5 - 3 |
| 5/1/21 6:00 PM | 5/1/21 6:00 PM | New England Revolution | Atlanta United FC | 2-1 | 4 - 5 - 4 |
| 5/1/21 6:30 PM | 5/1/21 6:30 PM | Orlando City | Cincinnati FC | 3-0 | 3 - 5 - 5 |
| 5/1/21 6:30 PM | 5/1/21 6:30 PM | Philadelphia Union | New York City FC | 0-2 | 4 - 5 - 4 |
| 5/1/21 7:00 PM | 5/1/21 7:00 PM | Minnesota United FC | Austin FC | 0-1 | 3 - 5 - 5 |
| 5/1/21 7:00 PM | 5/1/21 7:00 PM | FC Dallas | Portland Timbers | 4-1 | 4 - 5 - 4 |
| 5/1/21 10:00 PM | 5/1/21 10:00 PM | San Jose Earthquakes | D.C. United | 4-1 | 3 - 5 - 5 |
| 5/2/21 12:00 PM | 5/2/21 12:00 PM | Nashville SC | Inter Miami CF | 0-0 | 5 - 5 - 3 |
| 5/2/21 8:00 PM | 5/2/21 8:00 PM | Seattle Sounders | Los Angeles Galaxy | 3-0 | 4 - 5 - 4 |
| 5/2/21 9:00 PM | 5/2/21 9:00 PM | Vancouver Whitecaps | Colorado Rapids | 0-1 | 3 - 5 - 5 |