Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/2/21 2:30 PM | 10/2/21 2:30 PM | Austin FC | Real Salt Lake | 2-1 | 3 - 5 - 4 |
| 10/2/21 6:00 PM | 10/2/21 6:00 PM | CF Montreal | Atlanta United FC | 2-1 | 4 - 5 - 4 |
| 10/2/21 6:30 PM | 10/2/21 6:30 PM | Orlando City | D.C. United | 2-1 | 3 - 5 - 5 |
| 10/2/21 6:30 PM | 10/2/21 6:30 PM | Cincinnati FC | New York Red Bulls | 0-1 | 5 - 5 - 3 |
| 10/2/21 7:00 PM | 10/2/21 7:00 PM | FC Dallas | Minnesota United FC | 0-0 | 3 - 5 - 4 |
| 10/2/21 9:00 PM | 10/2/21 9:00 PM | Vancouver Whitecaps | San Jose Earthquakes | 3-0 | 3 - 5 - 5 |
| 10/3/21 11:00 AM | 10/3/21 11:00 AM | New York City FC | Nashville SC | 0-0 | 3 - 5 - 5 |
| 10/3/21 3:00 PM | 10/3/21 3:00 PM | Philadelphia Union | Columbus Crew | 3-0 | 3 - 5 - 5 |
| 10/3/21 3:00 PM | 10/3/21 3:00 PM | Sporting Kansas City | Houston Dynamo | 4-2 | 3 - 5 - 5 |
| 10/3/21 3:00 PM | 10/3/21 3:00 PM | Toronto FC | Chicago Fire | 3-1 | 3 - 5 - 5 |
| 10/3/21 4:30 PM | 10/3/21 4:30 PM | Portland Timbers | Inter Miami CF | 1-0 | 3 - 5 - 5 |
| 10/3/21 7:00 PM | 10/3/21 7:00 PM | Los Angeles Galaxy | Los Angeles FC | 1-1 | 3 - 5 - 5 |
| 10/3/21 9:00 PM | 10/3/21 9:00 PM | Seattle Sounders | Colorado Rapids | 3-0 | 3 - 5 - 5 |