Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/22/21 6:30 PM | 9/22/21 6:30 PM | Inter Miami CF | Nashville SC | 1-5 | 4 - 5 - 4 |
| 9/25/21 2:30 PM | 9/25/21 2:30 PM | Philadelphia Union | Atlanta United FC | 1-0 | 4 - 5 - 4 |
| 9/25/21 6:00 PM | 9/25/21 6:00 PM | New England Revolution | Orlando City | 2-1 | 3 - 5 - 5 |
| 9/25/21 6:30 PM | 9/25/21 6:30 PM | D.C. United | Cincinnati FC | 4-2 | 3 - 5 - 5 |
| 9/25/21 6:30 PM | 9/25/21 6:30 PM | Columbus Crew | CF Montreal | 2-1 | 3 - 5 - 4 |
| 9/25/21 7:00 PM | 9/25/21 7:00 PM | New York City FC | New York Red Bulls | 0-1 | 3 - 5 - 4 |
| 9/25/21 7:00 PM | 9/25/21 7:00 PM | Minnesota United FC | Houston Dynamo | 2-0 | 3 - 5 - 5 |
| 9/25/21 7:00 PM | 9/25/21 7:00 PM | Colorado Rapids | Toronto FC | 0-0 | 3 - 5 - 5 |
| 9/25/21 9:00 PM | 9/25/21 9:00 PM | San Jose Earthquakes | Los Angeles FC | 2-0 | 4 - 5 - 3 |
| 9/25/21 9:00 PM | 9/25/21 9:00 PM | Vancouver Whitecaps | FC Dallas | 1-0 | 3 - 5 - 5 |
| 9/25/21 9:30 PM | 9/25/21 9:30 PM | Portland Timbers | Real Salt Lake | 6-1 | 3 - 5 - 5 |
| 9/26/21 12:00 PM | 9/26/21 12:00 PM | Chicago Fire | Nashville SC | 0-0 | 4 - 5 - 4 |
| 9/26/21 6:00 PM | 9/26/21 6:00 PM | Sporting Kansas City | Seattle Sounders | 1-2 | 3 - 5 - 4 |
| 9/26/21 8:30 PM | 9/26/21 8:30 PM | Austin FC | Los Angeles Galaxy | 2-0 | 4 - 5 - 3 |