Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/17/21 6:00 PM | 9/17/21 6:00 PM | Inter Miami CF | New York Red Bulls | 0-4 | 3 - 5 - 4 |
| 9/18/21 2:30 PM | 9/18/21 2:30 PM | Atlanta United FC | D.C. United | 3-2 | 3 - 5 - 5 |
| 9/18/21 6:00 PM | 9/18/21 6:00 PM | New England Revolution | Columbus Crew | 1-1 | 3 - 5 - 5 |
| 9/18/21 6:30 PM | 9/18/21 6:30 PM | Cincinnati FC | New York City FC | 1-2 | 5 - 5 - 3 |
| 9/18/21 6:30 PM | 9/18/21 6:30 PM | Toronto FC | Nashville SC | 2-1 | 4 - 4 - 4 |
| 9/18/21 7:00 PM | 9/18/21 7:00 PM | Minnesota United FC | Los Angeles Galaxy | 3-0 | 4 - 5 - 4 |
| 9/18/21 7:00 PM | 9/18/21 7:00 PM | Austin FC | San Jose Earthquakes | 3-4 | 4 - 5 - 4 |
| 9/18/21 8:30 PM | 9/18/21 8:30 PM | Houston Dynamo | FC Dallas | 3-2 | 3 - 5 - 5 |
| 9/18/21 8:30 PM | 9/18/21 8:30 PM | Real Salt Lake | Seattle Sounders | 1-0 | 4 - 5 - 3 |
| 9/19/21 12:00 PM | 9/19/21 12:00 PM | CF Montreal | Chicago Fire | 2-0 | 3 - 5 - 5 |
| 9/19/21 3:00 PM | 9/19/21 3:00 PM | Philadelphia Union | Orlando City | 3-1 | 3 - 5 - 5 |
| 9/19/21 6:30 PM | 9/19/21 6:30 PM | Portland Timbers | Los Angeles FC | 2-1 | 4 - 5 - 4 |
| 9/19/21 8:00 PM | 9/19/21 8:00 PM | Colorado Rapids | Vancouver Whitecaps | 1-1 | 3 - 5 - 5 |