Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/3/21 6:30 PM | 9/3/21 6:30 PM | Philadelphia Union | New England Revolution | 0-1 | 3 - 5 - 4 |
| 9/14/21 6:30 PM | 9/14/21 6:30 PM | Columbus Crew | New York Red Bulls | 2-1 | 3 - 5 - 5 |
| 9/14/21 6:30 PM | 9/14/21 6:30 PM | New York City FC | FC Dallas | 3-3 | 3 - 5 - 5 |
| 9/14/21 6:30 PM | 9/14/21 6:30 PM | Toronto FC | Inter Miami CF | 0-1 | 4 - 5 - 4 |
| 9/15/21 6:00 PM | 9/15/21 6:00 PM | Atlanta United FC | Cincinnati FC | 4-0 | 3 - 5 - 5 |
| 9/15/21 6:30 PM | 9/15/21 6:30 PM | D.C. United | Chicago Fire | 3-0 | 3 - 5 - 5 |
| 9/15/21 6:30 PM | 9/15/21 6:30 PM | Orlando City | CF Montreal | 2-4 | 3 - 5 - 5 |
| 9/15/21 7:30 PM | 9/15/21 7:30 PM | Sporting Kansas City | Minnesota United FC | 4-0 | 3 - 5 - 5 |
| 9/15/21 8:00 PM | 9/15/21 8:00 PM | Austin FC | Los Angeles FC | 1-2 | 5 - 5 - 3 |
| 9/15/21 9:00 PM | 9/15/21 9:00 PM | Portland Timbers | Colorado Rapids | 2-2 | 3 - 5 - 5 |
| 9/15/21 9:30 PM | 9/15/21 9:30 PM | San Jose Earthquakes | Real Salt Lake | 3-4 | 3 - 5 - 5 |
| 9/15/21 9:30 PM | 9/15/21 9:30 PM | Los Angeles Galaxy | Houston Dynamo | 1-1 | 3 - 5 - 5 |
| 10/9/21 8:00 PM | 10/9/21 8:00 PM | Seattle Sounders | Vancouver Whitecaps | 4-1 | 3 - 5 - 5 |