Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/10/21 6:00 PM | 9/10/21 6:00 PM | Atlanta United FC | Orlando City | 3-0 | 3 - 5 - 5 |
| 9/10/21 9:00 PM | 9/10/21 9:00 PM | Vancouver Whitecaps | Portland Timbers | 0-1 | 3 - 5 - 5 |
| 9/11/21 2:30 PM | 9/11/21 2:30 PM | Colorado Rapids | Los Angeles Galaxy | 1-1 | 3 - 5 - 4 |
| 9/11/21 4:00 PM | 9/11/21 4:00 PM | Seattle Sounders | Minnesota United FC | 1-0 | 3 - 5 - 5 |
| 9/11/21 6:00 PM | 9/11/21 6:00 PM | New York Red Bulls | D.C. United | 1-1 | 3 - 5 - 4 |
| 9/11/21 6:00 PM | 9/11/21 6:00 PM | New England Revolution | New York City FC | 2-1 | 3 - 5 - 5 |
| 9/11/21 7:00 PM | 9/11/21 7:00 PM | Cincinnati FC | Toronto FC | 2-0 | 4 - 5 - 4 |
| 9/11/21 7:00 PM | 9/11/21 7:00 PM | CF Montreal | Nashville SC | 0-1 | 4 - 5 - 4 |
| 9/11/21 7:00 PM | 9/11/21 7:00 PM | Inter Miami CF | Columbus Crew | 1-0 | 3 - 5 - 4 |
| 9/11/21 7:30 PM | 9/11/21 7:30 PM | Sporting Kansas City | Chicago Fire | 2-0 | 3 - 5 - 5 |
| 9/11/21 7:30 PM | 9/11/21 7:30 PM | Houston Dynamo | Austin FC | 3-0 | 4 - 5 - 4 |
| 9/11/21 7:30 PM | 9/11/21 7:30 PM | FC Dallas | San Jose Earthquakes | 1-1 | 3 - 5 - 4 |
| 9/12/21 9:30 PM | 9/12/21 9:30 PM | Los Angeles FC | Real Salt Lake | 3-2 | 3 - 5 - 5 |