Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/3/21 6:30 PM | 9/3/21 6:30 PM | Nashville SC | New York City FC | 3-1 | 3 - 5 - 5 |
| 9/3/21 7:00 PM | 9/3/21 7:00 PM | Houston Dynamo | Portland Timbers | 0-2 | 4 - 5 - 4 |
| 9/3/21 9:00 PM | 9/3/21 9:00 PM | Los Angeles FC | Sporting Kansas City | 4-0 | 4 - 5 - 4 |
| 9/4/21 6:30 PM | 9/4/21 6:30 PM | Orlando City | Columbus Crew | 3-2 | 3 - 5 - 5 |
| 9/4/21 7:00 PM | 9/4/21 7:00 PM | Cincinnati FC | Inter Miami CF | 0-1 | 3 - 5 - 5 |
| 9/4/21 7:00 PM | 9/4/21 7:00 PM | Real Salt Lake | FC Dallas | 3-2 | 3 - 5 - 5 |
| 9/4/21 9:00 PM | 9/4/21 9:00 PM | San Jose Earthquakes | Colorado Rapids | 0-1 | 4 - 5 - 4 |