Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/27/21 5:30 PM | 8/27/21 5:30 PM | Columbus Crew | Cincinnati FC | 3-2 | 3 - 5 - 5 |
| 8/27/21 6:30 PM | 8/27/21 6:30 PM | CF Montreal | Toronto FC | 3-1 | 3 - 5 - 5 |
| 8/27/21 7:30 PM | 8/27/21 7:30 PM | Orlando City | Inter Miami CF | 0-0 | 3 - 5 - 5 |
| 8/28/21 2:30 PM | 8/28/21 2:30 PM | Atlanta United FC | Nashville SC | 0-2 | 3 - 5 - 5 |
| 8/28/21 5:00 PM | 8/28/21 5:00 PM | New York Red Bulls | Chicago Fire | 0-1 | 3 - 5 - 5 |
| 8/28/21 6:00 PM | 8/28/21 6:00 PM | Los Angeles FC | Los Angeles Galaxy | 3-3 | 3 - 5 - 4 |
| 8/28/21 6:30 PM | 8/28/21 6:30 PM | New York City FC | New England Revolution | 2-0 | 4 - 5 - 4 |
| 8/28/21 7:00 PM | 8/28/21 7:00 PM | D.C. United | Philadelphia Union | 3-1 | 5 - 5 - 3 |
| 8/28/21 8:00 PM | 8/28/21 8:00 PM | Houston Dynamo | Minnesota United FC | 1-2 | 4 - 5 - 4 |
| 8/28/21 8:00 PM | 8/28/21 8:00 PM | Sporting Kansas City | Colorado Rapids | 1-1 | 3 - 5 - 5 |
| 8/29/21 7:00 PM | 8/29/21 7:00 PM | Austin FC | FC Dallas | 3-5 | 4 - 5 - 4 |
| 8/29/21 9:00 PM | 8/29/21 9:00 PM | Vancouver Whitecaps | Real Salt Lake | 4-1 | 4 - 5 - 4 |
| 8/29/21 9:30 PM | 8/29/21 9:30 PM | Seattle Sounders | Portland Timbers | 0-2 | 3 - 5 - 5 |