Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/20/21 9:30 PM | 8/20/21 9:30 PM | Los Angeles Galaxy | San Jose Earthquakes | 1-2 | 3 - 5 - 5 |
| 8/21/21 2:30 PM | 8/21/21 2:30 PM | Minnesota United FC | Sporting Kansas City | 0-0 | 4 - 5 - 4 |
| 8/21/21 4:30 PM | 8/21/21 4:30 PM | Columbus Crew | Seattle Sounders | 1-2 | 5 - 4 - 3 |
| 8/21/21 7:00 PM | 8/21/21 7:00 PM | D.C. United | Atlanta United FC | 1-2 | 3 - 5 - 5 |
| 8/21/21 7:00 PM | 8/21/21 7:00 PM | Orlando City | Chicago Fire | 1-0 | 3 - 5 - 5 |
| 8/21/21 7:00 PM | 8/21/21 7:00 PM | New England Revolution | Cincinnati FC | 4-1 | 3 - 5 - 5 |
| 8/21/21 7:00 PM | 8/21/21 7:00 PM | Inter Miami CF | Toronto FC | 3-1 | 3 - 5 - 4 |
| 8/21/21 7:00 PM | 8/21/21 7:00 PM | Philadelphia Union | CF Montreal | 1-1 | 3 - 5 - 5 |
| 8/21/21 7:30 PM | 8/21/21 7:30 PM | Houston Dynamo | FC Dallas | 2-2 | 4 - 5 - 4 |
| 8/21/21 8:00 PM | 8/21/21 8:00 PM | Austin FC | Portland Timbers | 3-1 | 5 - 4 - 4 |
| 8/21/21 8:00 PM | 8/21/21 8:00 PM | Colorado Rapids | Real Salt Lake | 2-1 | 3 - 5 - 5 |
| 8/21/21 9:00 PM | 8/21/21 9:00 PM | Vancouver Whitecaps | Los Angeles FC | 2-1 | 4 - 5 - 4 |
| 9/22/21 7:00 PM | 9/22/21 7:00 PM | New York Red Bulls | New York City FC | 1-1 | 4 - 5 - 4 |