Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/17/21 9:30 PM | 8/17/21 9:30 PM | San Jose Earthquakes | Minnesota United FC | 1-1 | 3 - 5 - 4 |
| 8/17/21 9:30 PM | 8/17/21 9:30 PM | Los Angeles Galaxy | Colorado Rapids | 1-2 | 3 - 5 - 5 |
| 8/18/21 6:00 PM | 8/18/21 6:00 PM | New England Revolution | D.C. United | 3-2 | 3 - 5 - 5 |
| 8/18/21 6:00 PM | 8/18/21 6:00 PM | Atlanta United FC | Toronto FC | 1-0 | 3 - 5 - 5 |
| 8/18/21 6:30 PM | 8/18/21 6:30 PM | Inter Miami CF | Chicago Fire | 3-2 | 3 - 5 - 4 |
| 8/18/21 6:30 PM | 8/18/21 6:30 PM | Philadelphia Union | New York City FC | 1-0 | 4 - 5 - 4 |
| 8/18/21 6:30 PM | 8/18/21 6:30 PM | Cincinnati FC | CF Montreal | 0-0 | 3 - 5 - 4 |
| 8/18/21 7:00 PM | 8/18/21 7:00 PM | New York Red Bulls | Columbus Crew | 1-0 | 3 - 5 - 5 |
| 8/18/21 7:30 PM | 8/18/21 7:30 PM | Sporting Kansas City | Portland Timbers | 1-1 | 3 - 5 - 5 |
| 8/18/21 7:30 PM | 8/18/21 7:30 PM | Nashville SC | Orlando City | 1-1 | 3 - 4 - 5 |
| 8/18/21 7:30 PM | 8/18/21 7:30 PM | FC Dallas | Seattle Sounders | 0-1 | 5 - 5 - 3 |
| 8/18/21 8:00 PM | 8/18/21 8:00 PM | Austin FC | Vancouver Whitecaps | 1-2 | 3 - 5 - 4 |
| 8/18/21 9:00 PM | 8/18/21 9:00 PM | Real Salt Lake | Houston Dynamo | 2-1 | 3 - 5 - 5 |