Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/13/21 9:30 PM | 8/13/21 9:30 PM | San Jose Earthquakes | Vancouver Whitecaps | 0-0 | 3 - 5 - 5 |
| 8/14/21 5:00 PM | 8/14/21 5:00 PM | Minnesota United FC | Los Angeles Galaxy | 0-1 | 4 - 5 - 4 |
| 8/14/21 7:00 PM | 8/14/21 7:00 PM | Toronto FC | New England Revolution | 1-2 | 4 - 5 - 3 |
| 8/14/21 7:00 PM | 8/14/21 7:00 PM | CF Montreal | New York Red Bulls | 2-1 | 4 - 5 - 4 |
| 8/14/21 7:00 PM | 8/14/21 7:00 PM | New York City FC | Inter Miami CF | 2-0 | 3 - 5 - 5 |
| 8/14/21 7:30 PM | 8/14/21 7:30 PM | Houston Dynamo | Colorado Rapids | 1-3 | 4 - 4 - 4 |
| 8/14/21 7:30 PM | 8/14/21 7:30 PM | FC Dallas | Sporting Kansas City | 0-2 | 4 - 5 - 4 |
| 8/14/21 9:00 PM | 8/14/21 9:00 PM | Real Salt Lake | Austin FC | 1-0 | 3 - 5 - 5 |
| 8/15/21 3:00 PM | 8/15/21 3:00 PM | Atlanta United FC | Los Angeles FC | 1-0 | 4 - 5 - 4 |
| 8/15/21 5:00 PM | 8/15/21 5:00 PM | Chicago Fire | Columbus Crew | 1-0 | 3 - 5 - 4 |
| 8/15/21 6:00 PM | 8/15/21 6:00 PM | Nashville SC | D.C. United | 5-2 | 3 - 5 - 5 |
| 8/15/21 9:00 PM | 8/15/21 9:00 PM | Portland Timbers | Seattle Sounders | 2-6 | 4 - 5 - 4 |
| 10/9/21 7:00 PM | 10/9/21 7:00 PM | Cincinnati FC | Philadelphia Union | 1-2 | 5 - 5 - 3 |