Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/4/21 6:00 PM | 8/4/21 6:00 PM | New England Revolution | Nashville SC | 0-0 | 3 - 5 - 5 |
| 8/4/21 6:30 PM | 8/4/21 6:30 PM | Philadelphia Union | Toronto FC | 3-0 | 3 - 5 - 5 |
| 8/4/21 6:30 PM | 8/4/21 6:30 PM | CF Montreal | Atlanta United FC | 2-2 | 4 - 5 - 4 |
| 8/4/21 6:30 PM | 8/4/21 6:30 PM | Columbus Crew | D.C. United | 2-4 | 3 - 5 - 5 |
| 8/4/21 7:00 PM | 8/4/21 7:00 PM | New York Red Bulls | Cincinnati FC | 0-0 | 3 - 5 - 5 |
| 8/4/21 7:00 PM | 8/4/21 7:00 PM | Chicago Fire | New York City FC | 0-0 | 5 - 5 - 3 |
| 8/4/21 7:00 PM | 8/4/21 7:00 PM | Orlando City | Inter Miami CF | 1-1 | 3 - 5 - 5 |
| 8/4/21 8:00 PM | 8/4/21 8:00 PM | Austin FC | Houston Dynamo | 3-2 | 4 - 5 - 4 |
| 8/4/21 9:00 PM | 8/4/21 9:00 PM | Seattle Sounders | FC Dallas | 1-1 | 3 - 5 - 5 |
| 8/4/21 9:30 PM | 8/4/21 9:30 PM | Los Angeles Galaxy | Real Salt Lake | 1-0 | 3 - 5 - 5 |
| 8/4/21 9:30 PM | 8/4/21 9:30 PM | Portland Timbers | San Jose Earthquakes | 1-1 | 3 - 5 - 5 |
| 8/4/21 9:30 PM | 8/4/21 9:30 PM | Los Angeles FC | Sporting Kansas City | 1-4 | 3 - 5 - 4 |
| 10/10/21 3:00 PM | 10/10/21 3:00 PM | Minnesota United FC | Colorado Rapids | 1-3 | 3 - 5 - 4 |