Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 7/24/21 2:30 PM | 7/24/21 2:30 PM | Atlanta United FC | Columbus Crew | 0-1 | 3 - 5 - 5 |
| 7/24/21 7:00 PM | 7/24/21 7:00 PM | Chicago Fire | Toronto FC | 1-2 | 4 - 5 - 4 |
| 7/24/21 7:00 PM | 7/24/21 7:00 PM | Minnesota United FC | Portland Timbers | 2-1 | 3 - 5 - 4 |
| 7/24/21 7:30 PM | 7/24/21 7:30 PM | Nashville SC | Cincinnati FC | 3-0 | 3 - 5 - 5 |
| 7/24/21 7:30 PM | 7/24/21 7:30 PM | FC Dallas | Los Angeles Galaxy | 4-0 | 4 - 5 - 4 |
| 7/24/21 9:00 PM | 7/24/21 9:00 PM | San Jose Earthquakes | Houston Dynamo | 1-1 | 3 - 5 - 5 |
| 7/24/21 9:00 PM | 7/24/21 9:00 PM | Real Salt Lake | Colorado Rapids | 3-0 | 3 - 5 - 5 |
| 7/24/21 9:30 PM | 7/24/21 9:30 PM | Los Angeles FC | Vancouver Whitecaps | 2-2 | 3 - 5 - 5 |
| 7/25/21 5:00 PM | 7/25/21 5:00 PM | New England Revolution | CF Montreal | 2-1 | 3 - 5 - 5 |
| 7/25/21 5:00 PM | 7/25/21 5:00 PM | New York City FC | Orlando City | 5-0 | 4 - 4 - 4 |
| 7/25/21 6:30 PM | 7/25/21 6:30 PM | Inter Miami CF | Philadelphia Union | 1-1 | 5 - 5 - 3 |
| 7/25/21 7:00 PM | 7/25/21 7:00 PM | D.C. United | New York Red Bulls | 1-0 | 4 - 5 - 4 |
| 7/25/21 8:00 PM | 7/25/21 8:00 PM | Seattle Sounders | Sporting Kansas City | 1-3 | 3 - 5 - 5 |