Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 7/20/21 9:00 PM | 7/20/21 9:00 PM | Vancouver Whitecaps | Houston Dynamo | 0-0 | 4 - 5 - 4 |
| 7/21/21 6:30 PM | 7/21/21 6:30 PM | New York City FC | CF Montreal | 1-0 | 3 - 5 - 5 |
| 7/21/21 6:30 PM | 7/21/21 6:30 PM | Toronto FC | New York Red Bulls | 1-1 | 4 - 5 - 4 |
| 7/21/21 6:30 PM | 7/21/21 6:30 PM | Inter Miami CF | New England Revolution | 0-5 | 4 - 5 - 3 |
| 7/21/21 6:30 PM | 7/21/21 6:30 PM | Columbus Crew | Nashville SC | 0-0 | 3 - 4 - 5 |
| 7/21/21 7:00 PM | 7/21/21 7:00 PM | Cincinnati FC | Atlanta United FC | 1-1 | 3 - 5 - 4 |
| 7/21/21 7:00 PM | 7/21/21 7:00 PM | Chicago Fire | D.C. United | 2-2 | 3 - 5 - 5 |
| 7/21/21 7:30 PM | 7/21/21 7:30 PM | Sporting Kansas City | San Jose Earthquakes | 1-1 | 3 - 5 - 5 |
| 7/21/21 8:00 PM | 7/21/21 8:00 PM | Colorado Rapids | FC Dallas | 2-0 | 3 - 5 - 5 |
| 7/21/21 9:00 PM | 7/21/21 9:00 PM | Real Salt Lake | Los Angeles Galaxy | 2-2 | 3 - 5 - 4 |
| 7/21/21 9:30 PM | 7/21/21 9:30 PM | Portland Timbers | Los Angeles FC | 2-1 | 5 - 5 - 3 |
| 7/22/21 6:30 PM | 7/22/21 6:30 PM | Orlando City | Philadelphia Union | 2-1 | 3 - 5 - 5 |
| 7/22/21 8:30 PM | 7/22/21 8:30 PM | Austin FC | Seattle Sounders | 0-1 | 5 - 5 - 3 |