Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 6/12/21 2:00 PM | 6/12/21 2:00 PM | Sporting Kansas City | Austin FC | 1-1 | 3 - 5 - 5 |
| 7/17/21 4:00 PM | 7/17/21 4:00 PM | Atlanta United FC | New England Revolution | 0-1 | 4 - 5 - 4 |
| 7/17/21 6:30 PM | 7/17/21 6:30 PM | CF Montreal | Cincinnati FC | 5-4 | 3 - 5 - 5 |
| 7/17/21 6:30 PM | 7/17/21 6:30 PM | Toronto FC | Orlando City | 1-1 | 4 - 4 - 4 |
| 7/17/21 6:30 PM | 7/17/21 6:30 PM | Philadelphia Union | D.C. United | 2-1 | 3 - 5 - 5 |
| 7/17/21 6:30 PM | 7/17/21 6:30 PM | Columbus Crew | New York City FC | 2-1 | 3 - 5 - 5 |
| 7/17/21 7:30 PM | 7/17/21 7:30 PM | Nashville SC | Chicago Fire | 5-1 | 3 - 5 - 5 |
| 7/17/21 8:00 PM | 7/17/21 8:00 PM | Colorado Rapids | San Jose Earthquakes | 1-1 | 3 - 5 - 5 |
| 7/17/21 9:00 PM | 7/17/21 9:00 PM | Vancouver Whitecaps | Los Angeles Galaxy | 2-1 | 5 - 5 - 3 |
| 7/17/21 9:30 PM | 7/17/21 9:30 PM | Los Angeles FC | Real Salt Lake | 2-1 | 3 - 5 - 5 |
| 7/17/21 9:30 PM | 7/17/21 9:30 PM | Portland Timbers | FC Dallas | 1-0 | 3 - 5 - 5 |
| 7/18/21 1:00 PM | 7/18/21 1:00 PM | Minnesota United FC | Seattle Sounders | 1-0 | 5 - 5 - 3 |
| 10/9/21 5:00 PM | 10/9/21 5:00 PM | New York Red Bulls | Inter Miami CF | 1-0 | 3 - 5 - 5 |