Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 7/7/21 6:00 PM | 7/7/21 6:00 PM | New England Revolution | Toronto FC | 2-3 | 3 - 5 - 5 |
| 7/7/21 6:30 PM | 7/7/21 6:30 PM | CF Montreal | New York City FC | 2-1 | 5 - 4 - 3 |
| 7/7/21 7:00 PM | 7/7/21 7:00 PM | Chicago Fire | Orlando City | 3-1 | 4 - 5 - 3 |
| 7/7/21 8:00 PM | 7/7/21 8:00 PM | Austin FC | Los Angeles FC | 0-2 | 4 - 5 - 3 |
| 7/7/21 8:00 PM | 7/7/21 8:00 PM | Seattle Sounders | Houston Dynamo | 2-0 | 3 - 5 - 5 |
| 7/7/21 8:00 PM | 7/7/21 8:00 PM | Colorado Rapids | Minnesota United FC | 2-0 | 3 - 5 - 5 |
| 7/7/21 9:00 PM | 7/7/21 9:00 PM | Vancouver Whitecaps | Real Salt Lake | 0-4 | 5 - 5 - 3 |
| 7/7/21 9:30 PM | 7/7/21 9:30 PM | Los Angeles Galaxy | FC Dallas | 3-1 | 3 - 5 - 5 |
| 7/8/21 7:00 PM | 7/8/21 7:00 PM | New York Red Bulls | Philadelphia Union | 1-1 | 3 - 5 - 5 |
| 7/8/21 7:30 PM | 7/8/21 7:30 PM | Nashville SC | Atlanta United FC | 2-2 | 3 - 5 - 5 |
| 7/9/21 6:30 PM | 7/9/21 6:30 PM | Cincinnati FC | Columbus Crew | 2-2 | 5 - 5 - 3 |