Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/16/21 7:00 PM | 4/16/21 7:00 PM | Houston Dynamo | San Jose Earthquakes | 2-1 | 3 - 5 - 5 |
| 4/16/21 8:30 PM | 4/16/21 8:30 PM | Seattle Sounders | Minnesota United FC | 4-0 | 3 - 5 - 5 |
| 4/17/21 1:00 PM | 4/17/21 1:00 PM | CF Montreal | Toronto FC | 4-2 | 5 - 5 - 3 |
| 4/17/21 2:00 PM | 4/17/21 2:00 PM | Orlando City | Atlanta United FC | 0-0 | 4 - 5 - 4 |
| 4/17/21 5:00 PM | 4/17/21 5:00 PM | Los Angeles FC | Austin FC | 2-0 | 3 - 5 - 5 |
| 4/17/21 7:00 PM | 4/17/21 7:00 PM | D.C. United | New York City FC | 2-1 | 5 - 5 - 3 |
| 4/17/21 7:00 PM | 4/17/21 7:00 PM | FC Dallas | Colorado Rapids | 0-0 | 3 - 5 - 5 |
| 4/17/21 7:00 PM | 4/17/21 7:00 PM | New York Red Bulls | Sporting Kansas City | 1-2 | 3 - 5 - 5 |
| 4/17/21 7:30 PM | 4/17/21 7:30 PM | Chicago Fire | New England Revolution | 2-2 | 5 - 5 - 3 |
| 4/17/21 7:30 PM | 4/17/21 7:30 PM | Nashville SC | Cincinnati FC | 2-2 | 3 - 5 - 5 |
| 4/18/21 2:20 PM | 4/18/21 2:20 PM | Inter Miami CF | Los Angeles Galaxy | 2-3 | 4 - 5 - 4 |
| 4/18/21 4:30 PM | 4/18/21 4:30 PM | Columbus Crew | Philadelphia Union | 0-0 | 3 - 5 - 5 |
| 4/18/21 9:00 PM | 4/18/21 9:00 PM | Vancouver Whitecaps | Portland Timbers | 1-0 | 5 - 5 - 3 |