Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/21/21 11:45 AM | 9/21/21 11:45 AM | Fortuna Sittard | Ajax Amsterdam | 0-5 | 5 - 7 points |
| 9/21/21 2:00 PM | 9/21/21 2:00 PM | RKC Waalwijk | Willem II Tilburg | 1-2 | 5 - 7 points |
| 9/22/21 11:45 AM | 9/22/21 11:45 AM | NEC Nijmwegen | FC Utrecht | 0-3 | 5 - 7 points |
| 9/22/21 11:45 AM | 9/22/21 11:45 AM | Go Ahead Eagles Deventer | PSV Eindhoven | 1-2 | 5 - 7 points |
| 9/22/21 1:00 PM | 9/22/21 1:00 PM | FC Groningen | Vitesse Arnheim | 0-1 | 5 - 7 points |
| 9/22/21 2:00 PM | 9/22/21 2:00 PM | PEC Zwolle | Sparta Rotterdam | 1-1 | 5 - 7 points |
| 9/22/21 2:00 PM | 9/22/21 2:00 PM | Feyenoord Rotterdam | SC Heerenveen | 3-1 | 5 - 7 points |
| 9/23/21 11:45 AM | 9/23/21 11:45 AM | Cambuur-Leeuwarden | Heracles Almelo | 2-1 | 5 - 7 points |
| 9/23/21 2:00 PM | 9/23/21 2:00 PM | FC Twente Enschede | AZ Alkmaar | 3-1 | 5 - 7 points |