Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/17/21 1:00 PM | 9/17/21 1:00 PM | Sparta Rotterdam | NEC Nijmwegen | 1-1 | 5 - 7 points |
| 9/18/21 9:30 AM | 9/18/21 9:30 AM | SC Heerenveen | Fortuna Sittard | 1-0 | 5 - 7 points |
| 9/18/21 11:45 AM | 9/18/21 11:45 AM | Willem II Tilburg | FC Groningen | 2-1 | 5 - 7 points |
| 9/18/21 1:00 PM | 9/18/21 1:00 PM | Ajax Amsterdam | Cambuur-Leeuwarden | 9-0 | 5 - 7 points |
| 9/18/21 2:00 PM | 9/18/21 2:00 PM | FC Utrecht | RKC Waalwijk | 2-2 | 5 - 7 points |
| 9/19/21 5:15 AM | 9/19/21 5:15 AM | Go Ahead Eagles Deventer | PEC Zwolle | 1-0 | 5 - 7 points |
| 9/19/21 7:30 AM | 9/19/21 7:30 AM | PSV Eindhoven | Feyenoord Rotterdam | 0-4 | 5 - 7 points |
| 9/19/21 9:45 AM | 9/19/21 9:45 AM | Vitesse Arnheim | FC Twente Enschede | 1-4 | 5 - 7 points |
| 9/19/21 9:45 AM | 9/19/21 9:45 AM | Heracles Almelo | AZ Alkmaar | 3-2 | 5 - 7 points |