Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/20/21 9:30 AM | 11/20/21 9:30 AM | PSV Eindhoven | Vitesse Arnheim | 2-0 | 5 - 7 points |
| 11/20/21 11:45 AM | 11/20/21 11:45 AM | Sparta Rotterdam | FC Twente Enschede | 0-1 | 5 - 7 points |
| 11/20/21 1:00 PM | 11/20/21 1:00 PM | AZ Alkmaar | NEC Nijmwegen | 1-1 | 5 - 7 points |
| 11/20/21 2:00 PM | 11/20/21 2:00 PM | Heracles Almelo | Fortuna Sittard | 3-1 | 5 - 7 points |
| 11/21/21 5:15 AM | 11/21/21 5:15 AM | Go Ahead Eagles Deventer | FC Groningen | 0-1 | 5 - 7 points |
| 11/21/21 7:30 AM | 11/21/21 7:30 AM | SC Heerenveen | Willem II Tilburg | 2-1 | 5 - 7 points |
| 11/21/21 7:30 AM | 11/21/21 7:30 AM | Feyenoord Rotterdam | PEC Zwolle | 4-0 | 5 - 7 points |
| 11/21/21 9:45 AM | 11/21/21 9:45 AM | RKC Waalwijk | Ajax Amsterdam | 0-5 | 5 - 7 points |
| 11/21/21 1:00 PM | 11/21/21 1:00 PM | Cambuur-Leeuwarden | FC Utrecht | 2-1 | 5 - 7 points |