Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/30/21 9:30 AM | 10/30/21 9:30 AM | PSV Eindhoven | FC Twente Enschede | 5-2 | 5 - 7 points |
| 10/30/21 11:45 AM | 10/30/21 11:45 AM | Heracles Almelo | Ajax Amsterdam | 0-0 | 5 - 7 points |
| 10/30/21 1:00 PM | 10/30/21 1:00 PM | SC Heerenveen | Vitesse Arnheim | 1-2 | 5 - 7 points |
| 10/30/21 2:00 PM | 10/30/21 2:00 PM | AZ Alkmaar | PEC Zwolle | 3-2 | 5 - 7 points |
| 10/31/21 6:15 AM | 10/31/21 6:15 AM | Sparta Rotterdam | Feyenoord Rotterdam | 0-1 | 5 - 7 points |
| 10/31/21 8:30 AM | 10/31/21 8:30 AM | NEC Nijmwegen | FC Groningen | 3-0 | 5 - 7 points |
| 10/31/21 10:45 AM | 10/31/21 10:45 AM | RKC Waalwijk | Cambuur-Leeuwarden | 0-1 | 5 - 7 points |
| 10/31/21 10:45 AM | 10/31/21 10:45 AM | FC Utrecht | Willem II Tilburg | 5-1 | 5 - 7 points |
| 10/31/21 2:00 PM | 10/31/21 2:00 PM | Go Ahead Eagles Deventer | Fortuna Sittard | 4-3 | 5 - 7 points |