Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/11/21 6:30 AM | 9/11/21 6:30 AM | FC Ingolstadt | Werder Bremen | 0-3 | 5 - 7 points |
| 9/11/21 6:30 AM | 9/11/21 6:30 AM | Karlsruher SC | Holstein Kiel | 2-2 | 5 - 7 points |
| 9/11/21 6:30 AM | 9/11/21 6:30 AM | Hannover 96 | FC St. Pauli | 1-0 | 5 - 7 points |
| 9/11/21 1:30 PM | 9/11/21 1:30 PM | Hamburger SV | SV Sandhausen | 2-1 | 5 - 7 points |
| 9/12/21 6:30 AM | 9/12/21 6:30 AM | Jahn Regensburg | 1. FC Nürnberg | 2-2 | 5 - 7 points |
| 9/12/21 6:30 AM | 9/12/21 6:30 AM | FC Hansa Rostock | SV Darmstadt 98 | 2-1 | 5 - 7 points |
| 9/12/21 6:30 AM | 9/12/21 6:30 AM | 1. FC Heidenheim 1846 | Dynamo Dresden | 2-1 | 5 - 7 points |
| 9/12/21 6:30 AM | 9/12/21 6:30 AM | SC Paderborn 07 | FC Schalke 04 | 0-1 | 5 - 7 points |
| 9/12/21 6:30 AM | 9/12/21 6:30 AM | Erzgebirge Aue | Fortuna Düsseldorf | 0-1 | 5 - 7 points |