Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/9/21 8:00 AM | 10/9/21 8:00 AM | SV Spora | 1. FC Zeitz | 1-3 | 1 - 3 points |
| 10/9/21 8:00 AM | 10/9/21 8:00 AM | Wacker Wengelsdorf | SV Burgwerben | 1-1 | 1 - 3 points |
| 10/9/21 8:00 AM | 10/9/21 8:00 AM | SG Bad Bibra/Saubach | FC RSK Freyburg II | 0-2 | 1 - 3 points |
| 10/9/21 8:00 AM | 10/9/21 8:00 AM | Lossa/Rastenberg II | Germania Schönburg-Possenhain | 0-2 | 1 - 3 points |
| 10/9/21 8:00 AM | 10/9/21 8:00 AM | Gleinaer SV | SC Naumburg II | --- | 1 - 3 points |
| 10/9/21 8:00 AM | 10/9/21 8:00 AM | VSG 71 Löbitz | ESV Herrengosserstedt | 0-7 | 1 - 3 points |
| 10/9/21 8:00 AM | 10/9/21 8:00 AM | SV Kaiserpfalz | BSC 99 Laucha | 0-2 | 1 - 3 points |
| 10/9/21 8:00 AM | 10/9/21 8:00 AM | VfB Zeitz/Rasberg | SV Großgrimma | 1-5 | 1 - 3 points |
| 10/10/21 7:00 AM | 10/10/21 7:00 AM | Blau-Weiß Grana | Blau-Weiß Bad Kösen | 0-3 | 1 - 3 points |
| 10/10/21 7:00 AM | 10/10/21 7:00 AM | Lossa/Rastenberg | TSV Tröglitz | 3-2 | 1 - 3 points |