Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| PD | 9/25/21 7:00 AM | 9/25/21 7:00 AM | Deportivo Alaves | Atletico Madrid | 1-0 | 2 - 4 points |
| PD | 9/25/21 9:15 AM | 9/25/21 9:15 AM | FC Valencia | Athletic Bilbao | 1-1 | 2 - 4 points |
| SerA | 9/25/21 11:00 AM | 9/25/21 11:00 AM | Inter Milan | Atalanta Bergamo | 2-2 | 2 - 4 points |
| PD | 9/25/21 11:30 AM | 9/25/21 11:30 AM | FC Sevilla | Espanyol Barcelona | 2-0 | 2 - 4 points |
| PD | 9/25/21 2:00 PM | 9/25/21 2:00 PM | Real Madrid | FC Villarreal | 0-0 | 2 - 4 points |
| PD | 9/26/21 7:00 AM | 9/26/21 7:00 AM | RCD Mallorca | CA Osasuna | 2-3 | 2 - 4 points |
| PD | 9/26/21 9:15 AM | 9/26/21 9:15 AM | FC Barcelona | UD Levante | 3-0 | 2 - 4 points |
| SerA | 9/26/21 11:00 AM | 9/26/21 11:00 AM | Lazio Rom | AS Roma | 3-2 | 2 - 4 points |
| PD | 9/26/21 11:30 AM | 9/26/21 11:30 AM | Real Sociedad | FC Elche | 1-0 | 2 - 4 points |
| PD | 9/26/21 11:30 AM | 9/26/21 11:30 AM | Rayo Vallecano | FC Cadiz | 3-1 | 2 - 4 points |
| PD | 9/26/21 2:00 PM | 9/26/21 2:00 PM | Real Betis Sevilla | FC Getafe | 2-0 | 2 - 4 points |
| PD | 9/27/21 2:00 PM | 9/27/21 2:00 PM | Celta Vigo | FC Granada | 1-0 | 2 - 4 points |