Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| PD | 10/22/21 2:00 PM | 10/22/21 2:00 PM | CA Osasuna | FC Granada | 1-1 | 2 - 4 points |
| PD | 10/23/21 7:00 AM | 10/23/21 7:00 AM | FC Valencia | RCD Mallorca | 2-2 | 2 - 4 points |
| PD | 10/23/21 9:15 AM | 10/23/21 9:15 AM | FC Cadiz | Deportivo Alaves | 0-2 | 2 - 4 points |
| PD | 10/23/21 11:30 AM | 10/23/21 11:30 AM | FC Elche | Espanyol Barcelona | 2-2 | 2 - 4 points |
| PD | 10/23/21 2:00 PM | 10/23/21 2:00 PM | Athletic Bilbao | FC Villarreal | 2-1 | 2 - 4 points |
| PD | 10/24/21 7:00 AM | 10/24/21 7:00 AM | FC Sevilla | UD Levante | 5-3 | 2 - 4 points |
| PD | 10/24/21 9:15 AM | 10/24/21 9:15 AM | FC Barcelona | Real Madrid | 1-2 | 2 - 4 points |
| PL | 10/24/21 10:30 AM | 10/24/21 10:30 AM | Manchester United | Liverpool FC | 0-5 | 2 - 4 points |
| PD | 10/24/21 11:30 AM | 10/24/21 11:30 AM | Real Betis Sevilla | Rayo Vallecano | 3-2 | 2 - 4 points |
| SerA | 10/24/21 1:50 PM | 10/24/21 1:50 PM | Inter Milan | Juventus Turin | 1-1 | 2 - 4 points |
| PD | 10/24/21 2:00 PM | 10/24/21 2:00 PM | Atletico Madrid | Real Sociedad | 2-2 | 2 - 4 points |
| PD | 10/25/21 2:00 PM | 10/25/21 2:00 PM | FC Getafe | Celta Vigo | 0-3 | 2 - 4 points |