Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| SerA | 10/16/21 11:00 AM | 10/16/21 11:00 AM | Lazio Rom | Inter Milan | 3-1 | 2 - 4 points |
| PD | 10/16/21 11:30 AM | 10/16/21 11:30 AM | UD Levante | FC Getafe | 0-0 | 2 - 4 points |
| PD | 10/16/21 2:00 PM | 10/16/21 2:00 PM | Real Sociedad | RCD Mallorca | 1-0 | 2 - 4 points |
| PD | 10/17/21 7:00 AM | 10/17/21 7:00 AM | Rayo Vallecano | FC Elche | 2-1 | 2 - 4 points |
| GER1 | 10/17/21 8:30 AM | 10/17/21 8:30 AM | Bayer 04 Leverkusen | FC Bayern Munich | 1-5 | 2 - 4 points |
| PD | 10/17/21 9:15 AM | 10/17/21 9:15 AM | Celta Vigo | FC Sevilla | 0-1 | 2 - 4 points |
| PD | 10/17/21 11:30 AM | 10/17/21 11:30 AM | FC Villarreal | CA Osasuna | 1-2 | 2 - 4 points |
| PD | 10/17/21 2:00 PM | 10/17/21 2:00 PM | FC Barcelona | FC Valencia | 3-1 | 2 - 4 points |
| PD | 10/18/21 12:00 PM | 10/18/21 12:00 PM | Deportivo Alaves | Real Betis Sevilla | 0-1 | 2 - 4 points |
| PD | 10/18/21 2:00 PM | 10/18/21 2:00 PM | Espanyol Barcelona | FC Cadiz | 2-0 | 2 - 4 points |
| PD | 12/1/21 2:00 PM | 12/1/21 2:00 PM | Real Madrid | Athletic Bilbao | 1-0 | 2 - 4 points |
| PD | 12/22/21 12:00 PM | 12/22/21 12:00 PM | FC Granada | Atletico Madrid | 2-1 | 2 - 4 points |