Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| DFB | 10/26/21 11:30 AM | 10/26/21 11:25 AM | Preußen Münster | Hertha BSC | 1-3 | 2 - 4 points |
| DFB | 10/26/21 11:30 AM | 10/26/21 11:25 AM | SV Babelsberg 03 | RB Leipzig | 0-1 | 2 - 4 points |
| DFB | 10/26/21 11:30 AM | 10/26/21 11:25 AM | TSV 1860 Munich | FC Schalke 04 | 1-0 | 2 - 4 points |
| DFB | 10/26/21 11:30 AM | 10/26/21 11:25 AM | 1899 Hoffenheim | Holstein Kiel | 5-1 | 2 - 4 points |
| DFB | 10/26/21 1:00 PM | 10/26/21 12:55 PM | Borussia Dortmund | FC Ingolstadt | 2-0 | 2 - 4 points |
| DFB | 10/26/21 1:45 PM | 10/26/21 1:40 PM | 1. FC Nürnberg | Hamburger SV | 3-5a.PSO | 2 - 4 points |
| DFB | 10/26/21 1:45 PM | 10/26/21 1:40 PM | FSV Mainz 05 | Arminia Bielefeld | 3-2a.e.t | 2 - 4 points |
| DFB | 10/26/21 1:45 PM | 10/26/21 1:40 PM | VfL Osnabrück | SC Freiburg | 4-5a.PSO | 2 - 4 points |
| DFB | 10/27/21 11:30 AM | 10/27/21 11:25 AM | Dynamo Dresden | FC St. Pauli | 2-3a.e.t | 2 - 4 points |
| DFB | 10/27/21 11:30 AM | 10/27/21 11:25 AM | SV Waldhof Mannheim | 1. FC Union Berlin | 1-3a.e.t | 2 - 4 points |
| DFB | 10/27/21 11:30 AM | 10/27/21 11:25 AM | Bayer 04 Leverkusen | Karlsruher SC | 1-2 | 2 - 4 points |
| DFB | 10/27/21 11:30 AM | 10/27/21 11:25 AM | VfL Bochum | FC Augsburg | 7-6a.PSO | 2 - 4 points |
| DFB | 10/27/21 1:45 PM | 10/27/21 1:40 PM | Bor. Mönchengladbach | FC Bayern Munich | 5-0 | 2 - 4 points |
| DFB | 10/27/21 1:45 PM | 10/27/21 1:40 PM | Hannover 96 | Fortuna Düsseldorf | 3-0 | 2 - 4 points |
| DFB | 10/27/21 1:45 PM | 10/27/21 1:40 PM | Jahn Regensburg | FC Hansa Rostock | 5-7a.PSO | 2 - 4 points |
| DFB | 10/27/21 1:45 PM | 10/27/21 1:40 PM | VfB Stuttgart | 1. FC Köln | 0-2 | 2 - 4 points |