Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/22/21 1:30 PM | 10/22/21 1:30 PM | Alessandria Calcio | FC Crotone | 1-0 | 5 - 7 points |
| 10/23/21 7:00 AM | 10/23/21 7:00 AM | Benevento Calcio | Cosenza Calcio | 3-0 | 5 - 7 points |
| 10/23/21 7:00 AM | 10/23/21 7:00 AM | Ternana Calcio | Vicenza Calcio | 5-0 | 5 - 7 points |
| 10/23/21 7:00 AM | 10/23/21 7:00 AM | US Lecce | AC Perugia | 0-0 | 5 - 7 points |
| 10/23/21 7:00 AM | 10/23/21 7:00 AM | AC Monza | AS Cittadella | 1-0 | 5 - 7 points |
| 10/23/21 9:15 AM | 10/23/21 9:15 AM | Frosinone Calcio | Ascoli Calcio | 2-1 | 5 - 7 points |
| 10/23/21 11:30 AM | 10/23/21 11:30 AM | Brescia Calcio | US Cremonese | 1-0 | 5 - 7 points |
| 10/24/21 7:00 AM | 10/24/21 7:00 AM | Pisa Sporting Club | Pordenone | 1-1 | 5 - 7 points |
| 10/24/21 9:15 AM | 10/24/21 9:15 AM | Reggina 1914 | Parma Calcio 1913 | 2-1 | 5 - 7 points |
| 10/24/21 1:30 PM | 10/24/21 1:30 PM | SPAL Ferrara | Como Calcio | 1-1 | 5 - 7 points |