Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/16/21 7:00 AM | 10/16/21 7:00 AM | Pordenone | Ternana Calcio | 1-3 | 5 - 7 points |
| 10/16/21 7:00 AM | 10/16/21 7:00 AM | FC Crotone | Pisa Sporting Club | 2-1 | 5 - 7 points |
| 10/16/21 7:00 AM | 10/16/21 7:00 AM | Ascoli Calcio | US Lecce | 1-1 | 5 - 7 points |
| 10/16/21 7:00 AM | 10/16/21 7:00 AM | Vicenza Calcio | Reggina 1914 | 0-1 | 5 - 7 points |
| 10/16/21 9:15 AM | 10/16/21 9:15 AM | Cosenza Calcio | Frosinone Calcio | 1-1 | 5 - 7 points |
| 10/16/21 9:15 AM | 10/16/21 9:15 AM | AC Perugia | Brescia Calcio | 1-0 | 5 - 7 points |
| 10/16/21 11:30 AM | 10/16/21 11:30 AM | Como Calcio | Alessandria Calcio | 2-0 | 5 - 7 points |
| 10/17/21 7:00 AM | 10/17/21 7:00 AM | US Cremonese | Benevento Calcio | 1-1 | 5 - 7 points |
| 10/17/21 9:15 AM | 10/17/21 9:15 AM | Parma Calcio 1913 | AC Monza | 0-0 | 5 - 7 points |
| 10/17/21 1:30 PM | 10/17/21 1:30 PM | AS Cittadella | SPAL Ferrara | 0-0 | 5 - 7 points |