Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/1/21 1:30 PM | 10/1/21 1:30 PM | US Lecce | AC Monza | 3-0 | 5 - 7 points |
| 10/2/21 7:00 AM | 10/2/21 7:00 AM | Alessandria Calcio | Cosenza Calcio | 1-0 | 5 - 7 points |
| 10/2/21 7:00 AM | 10/2/21 7:00 AM | Frosinone Calcio | AS Cittadella | 0-1 | 5 - 7 points |
| 10/2/21 7:00 AM | 10/2/21 7:00 AM | US Cremonese | Ternana Calcio | 2-0 | 5 - 7 points |
| 10/2/21 7:00 AM | 10/2/21 7:00 AM | FC Crotone | Ascoli Calcio | 2-2 | 5 - 7 points |
| 10/2/21 9:15 AM | 10/2/21 9:15 AM | Pisa Sporting Club | Reggina 1914 | 2-0 | 5 - 7 points |
| 10/2/21 11:30 AM | 10/2/21 11:30 AM | SPAL Ferrara | Parma Calcio 1913 | 2-2 | 5 - 7 points |
| 10/3/21 7:00 AM | 10/3/21 7:00 AM | Brescia Calcio | Como Calcio | 2-4 | 5 - 7 points |
| 10/3/21 9:15 AM | 10/3/21 9:15 AM | Pordenone | Vicenza Calcio | 2-4 | 5 - 7 points |
| 10/3/21 1:30 PM | 10/3/21 1:30 PM | Benevento Calcio | AC Perugia | 0-0 | 5 - 7 points |