Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/25/21 7:00 AM | 9/25/21 7:00 AM | Ascoli Calcio | Brescia Calcio | 2-3 | 5 - 7 points |
| 9/25/21 7:00 AM | 9/25/21 7:00 AM | AS Cittadella | US Lecce | 1-2 | 5 - 7 points |
| 9/25/21 7:00 AM | 9/25/21 7:00 AM | Como Calcio | Benevento Calcio | 1-1 | 5 - 7 points |
| 9/25/21 7:00 AM | 9/25/21 7:00 AM | AC Monza | Pordenone | 3-1 | 5 - 7 points |
| 9/25/21 9:15 AM | 9/25/21 9:15 AM | Reggina 1914 | Frosinone Calcio | 0-0 | 5 - 7 points |
| 9/25/21 11:30 AM | 9/25/21 11:30 AM | Cosenza Calcio | FC Crotone | 1-0 | 5 - 7 points |
| 9/26/21 7:00 AM | 9/26/21 7:00 AM | AC Perugia | Alessandria Calcio | 1-1 | 5 - 7 points |
| 9/26/21 9:15 AM | 9/26/21 9:15 AM | Parma Calcio 1913 | Pisa Sporting Club | 1-1 | 5 - 7 points |
| 9/26/21 1:30 PM | 9/26/21 1:30 PM | Ternana Calcio | SPAL Ferrara | 1-0 | 5 - 7 points |
| 9/26/21 1:30 PM | 9/26/21 1:30 PM | Vicenza Calcio | US Cremonese | 0-1 | 5 - 7 points |