Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/20/21 1:30 PM | 9/20/21 1:30 PM | Frosinone Calcio | Brescia Calcio | 2-2 | 5 - 7 points |
| 9/21/21 11:00 AM | 9/21/21 11:00 AM | Alessandria Calcio | Ascoli Calcio | 1-3 | 5 - 7 points |
| 9/21/21 11:00 AM | 9/21/21 11:00 AM | Benevento Calcio | AS Cittadella | 4-1 | 5 - 7 points |
| 9/21/21 1:30 PM | 9/21/21 1:30 PM | Cosenza Calcio | Como Calcio | 2-0 | 5 - 7 points |
| 9/21/21 1:30 PM | 9/21/21 1:30 PM | FC Crotone | US Lecce | 0-3 | 5 - 7 points |
| 9/21/21 1:30 PM | 9/21/21 1:30 PM | Pordenone | Reggina 1914 | 1-1 | 5 - 7 points |
| 9/21/21 1:30 PM | 9/21/21 1:30 PM | SPAL Ferrara | Vicenza Calcio | 3-2 | 5 - 7 points |
| 9/21/21 1:30 PM | 9/21/21 1:30 PM | Pisa Sporting Club | AC Monza | 2-1 | 5 - 7 points |
| 9/22/21 11:00 AM | 9/22/21 11:00 AM | Ternana Calcio | Parma Calcio 1913 | 3-1 | 5 - 7 points |
| 9/22/21 1:30 PM | 9/22/21 1:30 PM | US Cremonese | AC Perugia | 0-3 | 5 - 7 points |