Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/17/21 11:00 AM | 9/17/21 11:00 AM | Como Calcio | Frosinone Calcio | 0-2 | 5 - 7 points |
| 9/17/21 1:30 PM | 9/17/21 1:30 PM | Brescia Calcio | FC Crotone | 2-2 | 5 - 7 points |
| 9/18/21 7:00 AM | 9/18/21 7:00 AM | AC Perugia | Cosenza Calcio | 1-1 | 5 - 7 points |
| 9/18/21 7:00 AM | 9/18/21 7:00 AM | Reggina 1914 | SPAL Ferrara | 2-1 | 5 - 7 points |
| 9/18/21 7:00 AM | 9/18/21 7:00 AM | Ascoli Calcio | Benevento Calcio | 0-2 | 5 - 7 points |
| 9/18/21 7:00 AM | 9/18/21 7:00 AM | AC Monza | Ternana Calcio | 1-1 | 5 - 7 points |
| 9/18/21 7:00 AM | 9/18/21 7:00 AM | US Lecce | Alessandria Calcio | 3-2 | 5 - 7 points |
| 9/18/21 9:15 AM | 9/18/21 9:15 AM | Vicenza Calcio | Pisa Sporting Club | 1-3 | 5 - 7 points |
| 9/18/21 11:30 AM | 9/18/21 11:30 AM | AS Cittadella | Pordenone | 1-0 | 5 - 7 points |
| 9/19/21 1:30 PM | 9/19/21 1:30 PM | Parma Calcio 1913 | US Cremonese | 1-2 | 5 - 7 points |