Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/10/21 1:30 PM | 9/10/21 1:30 PM | Benevento Calcio | US Lecce | 0-0 | 5 - 7 points |
| 9/11/21 7:00 AM | 9/11/21 7:00 AM | SPAL Ferrara | AC Monza | 1-1 | 5 - 7 points |
| 9/11/21 7:00 AM | 9/11/21 7:00 AM | Como Calcio | Ascoli Calcio | 0-1 | 5 - 7 points |
| 9/11/21 7:00 AM | 9/11/21 7:00 AM | Frosinone Calcio | AC Perugia | 0-0 | 5 - 7 points |
| 9/11/21 7:00 AM | 9/11/21 7:00 AM | Alessandria Calcio | Brescia Calcio | 1-3 | 5 - 7 points |
| 9/11/21 9:15 AM | 9/11/21 9:15 AM | Ternana Calcio | Pisa Sporting Club | 1-4 | 5 - 7 points |
| 9/11/21 11:30 AM | 9/11/21 11:30 AM | FC Crotone | Reggina 1914 | 1-1 | 5 - 7 points |
| 9/12/21 7:00 AM | 9/12/21 7:00 AM | Cosenza Calcio | Vicenza Calcio | 2-1 | 5 - 7 points |
| 9/12/21 9:15 AM | 9/12/21 9:15 AM | US Cremonese | AS Cittadella | 2-0 | 5 - 7 points |
| 9/12/21 1:30 PM | 9/12/21 1:30 PM | Pordenone | Parma Calcio 1913 | 0-4 | 5 - 7 points |