Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/25/21 8:00 AM | 9/25/21 8:00 AM | Union Bordeaux Bègles | CA Brive | 29-10 | 3 - 10 - 10 |
| 9/25/21 8:00 AM | 9/25/21 8:00 AM | Stade Français | Castres Olympique | 34-10 | 4 - 10 - 4 |
| 9/25/21 8:00 AM | 9/25/21 8:00 AM | Atlantique Stade Rochelais | Biarritz | 59-17 | 3 - 10 - 10 |
| 9/25/21 8:00 AM | 9/25/21 8:00 AM | Section Paloise | Montpellier Hérault RC | 23-22 | 4 - 10 - 4 |
| 9/25/21 10:00 AM | 9/25/21 10:00 AM | Racing Métro 92 | Lyon OU | 24-20 | 3 - 10 - 10 |
| 9/25/21 2:00 PM | 9/25/21 2:00 PM | USA Perpignan | RC Toulon | 12-9 | 4 - 10 - 4 |
| 9/26/21 2:05 PM | 9/26/21 2:05 PM | Stade Toulousain | ASM Clermont Auvergne | 27-15 | 3 - 10 - 10 |