Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/30/22 8:00 AM | 4/30/22 8:00 AM | Lyon OU | Montpellier Hérault RC | 43-20 | 3 - 10 - 7 |
| 4/30/22 10:00 AM | 4/30/22 10:00 AM | USA Perpignan | CA Brive | 27-10 | 3 - 10 - 8 |
| 4/30/22 10:00 AM | 4/30/22 10:00 AM | ASM Clermont Auvergne | Stade Français | 29-26 | 3 - 10 - 9 |
| 4/30/22 10:00 AM | 4/30/22 10:00 AM | Section Paloise | Racing Métro 92 | 21-42 | 6 - 10 - 3 |
| 4/30/22 10:00 AM | 4/30/22 10:00 AM | Biarritz | Castres Olympique | 13-48 | 7 - 10 - 3 |
| 4/30/22 2:05 PM | 4/30/22 2:05 PM | Stade Toulousain | Atlantique Stade Rochelais | 23-16 | 3 - 10 - 10 |
| 5/1/22 2:05 PM | 5/1/22 2:05 PM | Union Bordeaux Bègles | RC Toulon | 16-29 | 3 - 10 - 7 |