Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/24/21 1:45 PM | 9/24/21 1:45 PM | Club Brugge | OH Leuven | 1-1 | 5 - 7 points |
| 9/25/21 9:15 AM | 9/25/21 9:15 AM | K. Beerschot V.A. | KAS Eupen | 0-3 | 5 - 7 points |
| 9/25/21 11:30 AM | 9/25/21 11:30 AM | SV Zulte-Waregem | KV Kortrijk | 2-2 | 5 - 7 points |
| 9/25/21 1:45 PM | 9/25/21 1:45 PM | Standard Liège | Sint-Truidense VV | 1-2 | 5 - 7 points |
| 9/26/21 6:30 AM | 9/26/21 6:30 AM | Royale Union Saint-Gilloise | Royal Antwerp FC | 1-2 | 5 - 7 points |
| 9/26/21 9:00 AM | 9/26/21 9:00 AM | KAA Gent | KSV Cercle Brügge | 2-1 | 5 - 7 points |
| 9/26/21 11:30 AM | 9/26/21 11:30 AM | KV Oostende | RSC Anderlecht | 2-2 | 5 - 7 points |
| 9/26/21 2:00 PM | 9/26/21 2:00 PM | KRC Genk | RFC Seraing | 3-0 | 5 - 7 points |
| 9/26/21 2:00 PM | 9/26/21 2:00 PM | Sporting Charleroi | KV Mechelen | 0-2 | 5 - 7 points |