Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/1/22 1:45 PM | 4/1/22 1:45 PM | K. Beerschot V.A. | Club Brugge | 1-3 | 5 - 7 points |
| 4/2/22 9:15 AM | 4/2/22 9:15 AM | SV Zulte-Waregem | Sint-Truidense VV | 0-2 | 5 - 7 points |
| 4/2/22 11:30 AM | 4/2/22 11:30 AM | KV Mechelen | KV Kortrijk | 3-2 | 5 - 7 points |
| 4/2/22 11:30 AM | 4/2/22 11:30 AM | KV Oostende | RFC Seraing | 2-2 | 5 - 7 points |
| 4/2/22 1:45 PM | 4/2/22 1:45 PM | OH Leuven | Royal Antwerp FC | 0-1 | 5 - 7 points |
| 4/3/22 6:30 AM | 4/3/22 6:30 AM | Standard Liège | Royale Union Saint-Gilloise | 1-3 | 5 - 7 points |
| 4/3/22 9:00 AM | 4/3/22 9:00 AM | KSV Cercle Brügge | KAA Gent | 2-2 | 5 - 7 points |
| 4/3/22 11:30 AM | 4/3/22 11:30 AM | RSC Anderlecht | Sporting Charleroi | 4-0 | 5 - 7 points |
| 4/3/22 2:00 PM | 4/3/22 2:00 PM | KRC Genk | KAS Eupen | 5-0 | 5 - 7 points |