Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 3/18/22 2:45 PM | 3/18/22 2:45 PM | Royale Union Saint-Gilloise | KV Oostende | 1-1 | 5 - 7 points |
| 3/19/22 10:15 AM | 3/19/22 10:15 AM | KAS Eupen | KV Mechelen | 1-1 | 5 - 7 points |
| 3/19/22 12:30 PM | 3/19/22 12:30 PM | RFC Seraing | OH Leuven | 1-1 | 5 - 7 points |
| 3/19/22 12:30 PM | 3/19/22 12:30 PM | Sporting Charleroi | KSV Cercle Brügge | 5-0 | 5 - 7 points |
| 3/19/22 2:45 PM | 3/19/22 2:45 PM | Royal Antwerp FC | SV Zulte-Waregem | 1-0 | 5 - 7 points |
| 3/20/22 7:30 AM | 3/20/22 7:30 AM | Club Brugge | KRC Genk | 3-1 | 5 - 7 points |
| 3/20/22 10:00 AM | 3/20/22 10:00 AM | KV Kortrijk | Standard Liège | 0-1 | 5 - 7 points |
| 3/20/22 12:30 PM | 3/20/22 12:30 PM | KAA Gent | RSC Anderlecht | 1-0 | 5 - 7 points |
| 3/20/22 3:00 PM | 3/20/22 3:00 PM | Sint-Truidense VV | K. Beerschot V.A. | 3-2 | 5 - 7 points |