Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/17/21 1:45 PM | 12/17/21 1:45 PM | RFC Seraing | KV Kortrijk | 0-2 | 5 - 7 points |
| 12/18/21 9:15 AM | 12/18/21 9:15 AM | K. Beerschot V.A. | KV Oostende | 0-2 | 5 - 7 points |
| 12/18/21 11:30 AM | 12/18/21 11:30 AM | SV Zulte-Waregem | KV Mechelen | 3-2 | 5 - 7 points |
| 12/18/21 11:30 AM | 12/18/21 11:30 AM | Royale Union Saint-Gilloise | KSV Cercle Brügge | 3-2 | 5 - 7 points |
| 12/18/21 1:45 PM | 12/18/21 1:45 PM | KAA Gent | Sint-Truidense VV | 2-1 | 5 - 7 points |
| 12/19/21 6:30 AM | 12/19/21 6:30 AM | Club Brugge | RSC Anderlecht | 2-2 | 5 - 7 points |
| 12/19/21 9:00 AM | 12/19/21 9:00 AM | KAS Eupen | Sporting Charleroi | 0-4 | 5 - 7 points |
| 12/19/21 11:30 AM | 12/19/21 11:30 AM | KRC Genk | Royal Antwerp FC | 1-1 | 5 - 7 points |
| 12/19/21 2:00 PM | 12/19/21 2:00 PM | OH Leuven | Standard Liège | 2-1 | 5 - 7 points |