Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/14/21 11:45 AM | 12/14/21 11:45 AM | KSV Cercle Brügge | RFC Seraing | 2-0 | 5 - 7 points |
| 12/14/21 2:00 PM | 12/14/21 2:00 PM | RSC Anderlecht | Sint-Truidense VV | 2-0 | 5 - 7 points |
| 12/14/21 2:00 PM | 12/14/21 2:00 PM | KV Oostende | KV Kortrijk | 0-2 | 5 - 7 points |
| 12/15/21 11:45 AM | 12/15/21 11:45 AM | KV Mechelen | KAA Gent | 4-3 | 5 - 7 points |
| 12/15/21 11:45 AM | 12/15/21 11:45 AM | SV Zulte-Waregem | Royale Union Saint-Gilloise | 0-2 | 5 - 7 points |
| 12/15/21 2:00 PM | 12/15/21 2:00 PM | OH Leuven | Club Brugge | 1-4 | 5 - 7 points |
| 12/16/21 11:45 AM | 12/16/21 11:45 AM | Royal Antwerp FC | KAS Eupen | 4-2 | 5 - 7 points |
| 12/16/21 2:00 PM | 12/16/21 2:00 PM | KRC Genk | Sporting Charleroi | 4-2 | 5 - 7 points |
| 3/2/22 11:45 AM | 3/2/22 11:45 AM | Standard Liège | K. Beerschot V.A. | 1-0 | 5 - 7 points |