Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/29/21 1:45 PM | 10/29/21 1:45 PM | KV Oostende | KV Mechelen | 2-4 | 5 - 7 points |
| 10/30/21 9:15 AM | 10/30/21 9:15 AM | Sporting Charleroi | KAS Eupen | 3-0 | 5 - 7 points |
| 10/30/21 11:30 AM | 10/30/21 11:30 AM | K. Beerschot V.A. | RFC Seraing | 3-0 | 5 - 7 points |
| 10/30/21 11:30 AM | 10/30/21 11:30 AM | Standard Liège | KV Kortrijk | 1-1 | 5 - 7 points |
| 10/30/21 1:45 PM | 10/30/21 1:45 PM | Sint-Truidense VV | Club Brugge | 1-2 | 5 - 7 points |
| 10/31/21 7:30 AM | 10/31/21 7:30 AM | SV Zulte-Waregem | KRC Genk | 2-6 | 5 - 7 points |
| 10/31/21 10:00 AM | 10/31/21 10:00 AM | KSV Cercle Brügge | Royal Antwerp FC | 0-1 | 5 - 7 points |
| 10/31/21 12:30 PM | 10/31/21 12:30 PM | RSC Anderlecht | OH Leuven | 2-2 | 5 - 7 points |
| 10/31/21 3:00 PM | 10/31/21 3:00 PM | KAA Gent | Royale Union Saint-Gilloise | 0-2 | 5 - 7 points |