| Date | Home | Away | Result |
|---|---|---|---|
| 9/26/25 1:45 PM | OH Leuven | RSC Anderlecht | 1-1 |
| 9/27/25 9:00 AM | SV Zulte-Waregem | Royal Antwerp FC | 2-0 |
| 9/27/25 11:15 AM | Standard Liège | Club Brugge | 1-2 |
| 9/27/25 1:45 PM | Royale Union Saint-Gilloise | KVC Westerlo | 2-0 |
| 9/28/25 6:30 AM | Sint-Truidense VV | KRC Genk | 1-2 |
| 9/28/25 9:00 AM | KSV Cercle Brügge | KAA Gent | 2-4 |
| 9/28/25 11:30 AM | Sporting Charleroi | KV Mechelen | 0-2 |
| 9/28/25 12:15 PM | FCV Dender EH | RAAL La Louviere | 0-0 |