| Date | Home | Away | Result |
|---|---|---|---|
| 9/19/25 1:45 PM | KAA Gent | FCV Dender EH | 3-0 |
| 9/20/25 9:00 AM | OH Leuven | RAAL La Louviere | 1-2 |
| 9/20/25 11:15 AM | Sporting Charleroi | SV Zulte-Waregem | 1-2 |
| 9/20/25 1:45 PM | RSC Anderlecht | Royal Antwerp FC | 0-0 |
| 9/21/25 6:30 AM | KRC Genk | Royale Union Saint-Gilloise | 1-2 |
| 9/21/25 9:00 AM | KVC Westerlo | Standard Liège | 0-2 |
| 9/21/25 11:30 AM | Club Brugge | Sint-Truidense VV | 2-0 |
| 9/21/25 12:15 PM | KV Mechelen | KSV Cercle Brügge | 0-0 |