| Date | Home | Away | Result |
|---|---|---|---|
| 9/2/22 1:45 PM | Club Brugge | KSV Cercle Brügge | 4-0 |
| 9/3/22 9:00 AM | KRC Genk | Sint-Truidense VV | 0-0 |
| 9/3/22 11:15 AM | KV Mechelen | RFC Seraing | 2-3 |
| 9/3/22 11:15 AM | KAS Eupen | KV Kortrijk | 0-1 |
| 9/3/22 1:45 PM | Standard Liège | KV Oostende | 1-0 |
| 9/4/22 6:30 AM | RSC Anderlecht | OH Leuven | 2-2 |
| 9/4/22 9:00 AM | Royal Antwerp FC | KVC Westerlo | 3-0 |
| 9/4/22 11:30 AM | Sporting Charleroi | KAA Gent | 2-1 |
| 9/4/22 2:00 PM | SV Zulte-Waregem | Royale Union Saint-Gilloise | 1-3 |