| Date | Home | Away | Result |
|---|---|---|---|
| 9/12/25 1:45 PM | Standard Liège | KV Mechelen | 1-1 |
| 9/13/25 9:00 AM | SV Zulte-Waregem | OH Leuven | 2-0 |
| 9/13/25 11:15 AM | FCV Dender EH | Royale Union Saint-Gilloise | 0-1 |
| 9/13/25 1:45 PM | RAAL La Louviere | Club Brugge | 1-0 |
| 9/14/25 6:30 AM | Royal Antwerp FC | KAA Gent | 1-2 |
| 9/14/25 9:00 AM | KSV Cercle Brügge | Sporting Charleroi | 2-3 |
| 9/14/25 11:30 AM | RSC Anderlecht | KRC Genk | 1-1 |
| 9/14/25 12:15 PM | Sint-Truidense VV | KVC Westerlo | 0-3 |