| Date | Home | Away | Result |
|---|---|---|---|
| 8/19/22 1:45 PM | KAS Eupen | RFC Seraing | 1-3 |
| 8/20/22 9:00 AM | KV Oostende | Sint-Truidense VV | 0-1 |
| 8/20/22 11:15 AM | KRC Genk | KSV Cercle Brügge | 2-1 |
| 8/21/22 6:30 AM | Club Brugge | KV Kortrijk | 2-1 |
| 8/21/22 9:00 AM | SV Zulte-Waregem | Sporting Charleroi | 1-3 |
| 8/21/22 11:30 AM | Standard Liège | OH Leuven | 1-3 |
| 8/21/22 2:00 PM | KV Mechelen | KVC Westerlo | 5-4 |
| 8/31/22 1:30 PM | Royal Antwerp FC | Royale Union Saint-Gilloise | 4-2 |
| 9/1/22 1:30 PM | RSC Anderlecht | KAA Gent | 0-1 |