| Date | Home | Away | Result |
|---|---|---|---|
| 8/12/22 1:45 PM | KV Oostende | KAA Gent | 1-3 |
| 8/13/22 9:00 AM | KVC Westerlo | Standard Liège | 4-2 |
| 8/13/22 11:15 AM | KSV Cercle Brügge | KV Mechelen | 0-0 |
| 8/13/22 11:15 AM | RFC Seraing | Sporting Charleroi | 0-1 |
| 8/13/22 1:45 PM | Royale Union Saint-Gilloise | KV Kortrijk | 2-1 |
| 8/14/22 6:30 AM | Sint-Truidense VV | RSC Anderlecht | 0-3 |
| 8/14/22 9:00 AM | KAS Eupen | Royal Antwerp FC | 0-1 |
| 8/14/22 11:30 AM | OH Leuven | Club Brugge | 0-3 |
| 8/14/22 2:00 PM | SV Zulte-Waregem | KRC Genk | 1-4 |