| Date | Home | Away | Result |
|---|---|---|---|
| 5/9/25 1:45 PM | Sporting Charleroi | KVC Westerlo | 4-3 |
| 5/10/25 9:00 AM | K. Beerschot V.A. | KSV Cercle Brügge | 4-2 |
| 5/10/25 9:00 AM | KV Kortrijk | Sint-Truidense VV | 2-2 |
| 5/10/25 11:15 AM | KV Mechelen | Standard Liège | 0-0 |
| 5/10/25 1:45 PM | RSC Anderlecht | Royale Union Saint-Gilloise | 0-1 |
| 5/11/25 6:30 AM | KAA Gent | Royal Antwerp FC | 0-3 |
| 5/11/25 11:30 AM | KRC Genk | Club Brugge | 0-2 |
| 5/11/25 12:15 PM | FCV Dender EH | OH Leuven | 5-0 |